EAJAIC
Eurasian Journal of Anesthesiology and Intensive Care

The Eurasian Journal of Anesthesiology and Intensive Care (EAJAIC) is an independent-unbiased, peer-reviewed, "double-blind", and open-access journal of current national and international issues and reviews for original clinical and experimental research, interesting case reports, differential diagnoses, editorial opinions, letters to the editor, and educational papers in anesthesiology, algology, and intensive care medicine.

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eISSN: 3023-6738
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Original Article
The progression of biochemical parameters and disease severity scores in patients with septic shock: a study of sequential measurements
Abstract
Aims: Sepsis and septic shock are critical conditions that contribute significantly to morbidity and mortality in intensive care units worldwide. Early diagnosis and treatment are crucial for improving survival, yet traditional diagnostic methods lack sensitivity. Biomarkers like C-reactive protein and procalcitonin, along with disease severity scores such as APACHE II, SOFA, and MODS, are increasingly used to assess patient status and predict outcomes. This study aims to explore the relationship between inflammatory biomarkers and disease severity scores in critically ill patients with septic shock.
Methods: This prospective study included 20 patients with septic shock admitted to the intensive care unit between July and September 2009. C-reactive protein, procalcitonin, cortisol, brain natriuretic peptide, lactate, and other physiological parameters were monitored over a three-day period. Disease severity was assessed using APACHE II, SOFA, and MODS scores, with mortality outcomes recorded. Data was analyzed using Spearman’s correlation analysis.
Results: The study found no significant correlation between APACHE II scores at admission and 28-day mortality. However, both SOFA and MODS scores showed significant correlations with 28-day mortality when measured on the second and third days of intensive care unit admission. C-reactive protein and procalcitonin levels were elevated in all patients, yet no direct correlation with 28-day mortality was identified. Sequential monitoring of SOFA and MODS scores was more predictive of patient outcomes than single-day measurements.
Conclusion: Sequential assessments of disease severity scores provide valuable insights into the progression of septic shock. While C-reactive protein and procalcitonin are useful in monitoring infection, they alone may not be sufficient to predict mortality. In contrast, dynamic measurements of SOFA and MODS scores are better indicators of patient prognosis, particularly when combined with biomarker data. Continuous monitoring of disease severity scores, particularly SOFA and MODS, alongside biomarkers such as C-reactive protein and procalcitonin, enhances the prediction of mortality in septic shock patients. These tools, when used together, offer a comprehensive approach to managing critically ill patients in the intensive care unit, allowing for timely and effective interventions.

Keywords : Apache, biomarkers, organ dysfunction scores, sepsis, septic shock

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Article available in :
Volume 1, Issue 4, 2024
Page : 86-91
https://doi.org/10.51271/EAJAIC-0018
Article Information
Received : 19 Eyl 2024
Accepted : 01 Eki 2024
Published : 15 Eki 2024
Corresponding Author :

Arif Timuroğlu: Department of Anesthesiology and Reanimation, Dr. Abdurrahman Yurtaslan Ankara Oncology Hospital, Ankara, Turkiye

[email protected]
Citation : Timuroğlu A, Yılmaz AA, Tulunay M. The progression of biochemical parameters and disease severity scores in patients with septic shock: a study of sequential measurements. Eur J Anesthesiol Intensive Care. 2024;1(4):86-91.

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