EAJAIC
Eurasian Journal of Anesthesiology and Intensive Care

The Eurasian Journal of Anesthesiology and Intensive Care (EAJAIC) is an independent-unbiased, peer-reviewed, "double-blind", and open-access journal of current national and international issues and reviews for original clinical and experimental research, interesting case reports, differential diagnoses, editorial opinions, letters to the editor, and educational papers in anesthesiology, algology, and intensive care medicine.

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Original Article
Association of inflammatory markers (Inflammatory Burden Index, Systemic Inflammation Response Index, Systemic Immune-Inflammation Index) and modified Glasgow Prognostic Score with 30- and 90-day mortality in a level 3 surgical intensive care unit
Abstract
Aims: We aimed to examine the relationship between systemic inflammatory markers and mGPS with 30- and 90-day mortality in critically ill patients who underwent various types of surgery (abdominal, neurosurgical, orthopedic, and urogynecological surgeries) and were followed up in a tertiary surgical intensive care unit.
Methods: This retrospective study included patients who were postoperatively followed in the tertiary surgical intensive care unit between January 2021-2025. A total of 455 patients were included in the study. Data regarding patients’ age, comorbidities, length of hospital stay, length of intensive care unit stay, preoperative 24-hour inflammatory parameters (leukocyte, neutrophil, platelet, lymphocyte, monocyte, CRP, albumin, procalcitonin), and APACHE II and SAPS II scores at intensive care unit admission were collected. Composite inflammatory biomarkers (IBI, SIRI, SII, mGPS) were calculated using formulas.
Results: A total of 455 postoperative patients were included in the study. Among them, 270 (59.3%) were male, and the mean age was 69.69?±?17.18 years. Of all patients, 193 (42.2%) underwent abdominal surgery, 74 (16.3%) underwent neurosurgery, 140(30.8%) underwent orthopedic surgery, and 48 (10.5%) underwent urogynecological surgery. Among the inflammatory indices, the Inflammatory Burden Index (p = 0.001 for 30-day, p < 0.001 for 90-day), Neutrophil-to-Lymphocyte Ratio(p = 0.029 for 30-day, p = 0.033 for 90-day), and Modified Glasgow Prognostic Score (p = 0.005 for 30-day, p < 0.001 for 90-day) were significant predictors of both short- and mid-term mortality.
Conclusion: Among postoperative surgical patients, Inflammatory Burden Index and Modified Glasgow Prognostic Score are significant predictors of 30/90 day mortality.

Keywords : Inflammatory Burden Index, Systemic Inflammatory Response Index, Systemic Immune-Inflammation Index, Modified Glasgow Prognostic Score, mortality, post-surgical patients

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1. Xie H, Ruan G, Ge Y, et al. Inflammatory burden as a prognostic biomarker for cancer. Clin Nutr. 2022;41(6):1236-1243. doi: 10.1016/j.clnu.2022.04.019
2. Xie H, Ruan G, Wei L, et al. Comprehensive comparative analysis of prognostic value of serum systemic inflammation biomarkers for colorectal cancer: results from a large multicenter collaboration. Front Immunol. 2023;13:1092498. doi: 10.3389/fimmu.2022.1092498
3. Qi X, Li Y, Fang C, et al. The associations between dietary fibers intake and systemic immune and inflammatory biomarkers, a multi-cycle study of NHANES 2015-2020. Front Nutr. 2023;10:1216445. doi: 10.3389/fnut.2023.1242115
4. Biyik M, Biyik Z, Asil M, Keskin M. Systemic Inflammation Response Index and Systemic Immune Inflammation Index are associated with clinical outcomes in patients with acute pancreatitis? J Invest Surg. 2022;35(8):1613-1620. doi: 10.1080/08941939.2022.2084187
5. Zhao M, Duan X, Mi L, et al. Prognosis of hepatocellular carcinoma and its association with immune cells using Systemic Inflammatory Response Index. Future Oncol. 2022;18(18):2269-2288. doi: 10.2217/fon-2021-1087
6. Xia Y, Xia C, Wu L, Li Z, Li H, Zhang J. Systemic Immune Inflammation Index (SII), System İnflammation Response Index (SIRI) and risk of all-cause mortality and cardiovascular mortality: a 20-year follow-up cohort study of 42,875 US adults. J Clin Med. 2023;12(3):1128. doi: 10.3390/jcm12031128
7. Wang RH, Wen WX, Jiang ZP, et al. The clinical value of neutrophil-to-lymphocyte ratio (NLR), Systemic Immune-Inflammation Index (SII), platelet-to-lymphocyte ratio (PLR) and Systemic Inflammation Response Index (SIRI) for predicting the occurrence and severity of pneumonia in patients with intracerebral hemorrhage. Front Immunol. 2023;14:1115031. doi: 10.3389/fimmu.2023.1115031
8. Huang H, Liu Q, Zhu L, et al. Prognostic value of preoperative Systemic Immune-Inflammation Index in patients with cervical cancer. Sci Rep. 2019 ;9(1):3284. doi: 10.1038/s41598-019-39150-0
9. Son W, Shin SJ, Park SH, et al. Clinical impact of combined modified Glasgow Prognostic Score and C-reactive protein/albumin ratio in patients with colorectal cancer. Diagnostics (Basel). 2020;10(11):859. doi: 10.3390/diagnostics10110859
10. Dolan RD, McSorley ST, Park JH, et al. The prognostic value of systemic inflammation in patients undergoing surgery for colon cancer: comparison of composite ratios and cumulative scores. Br J Cancer. 2018;119(1):40-51. doi: 10.1038/s41416-018-0095-9
11. Cui C, Wu X, Deng L, Wang W, Cui W, Wang Y. Modified Glasgow Prognostic Score predicts the prognosis of patients with advanced esophageal squamous cell carcinoma: a propensity score-matched analysis. Thorac Cancer. 2022;13(14):2041-2049. doi: 10.1111/1759-7714.14486
12. Pelc Z, Sedlak K, Mlak R, et al. Prognostic value of Inflammatory Burden Index in advanced gastric cancer patients undergoing multimodal treatment. Cancers (Basel). 2024;16(4):828. doi: 10.3390/cancers16040828
13. Ye C, Yuan L, Wu K, Shen B, Zhu C. Association between Systemic Immune-Inflammation Index and chronic obstructive pulmonary disease: a population-based study. BMC Pulm Med. 2023;23(1):295. doi: 10.1186/s12890-023-02583-5
14. Song Z, Lin F, Chen Y, et al. Inflammatory Burden Index: association between novel systemic inflammatory biomarkers and prognosis as well as in-hospital complications of patients with aneurysmal subarachnoid hemorrhage. J Inflamm Res. 2023;16:3911-3921. doi: 10.2147/JIR.S416295
15. Li L, Zinger J, Sassen SDT, Juffermans NP, Koch BCP, Endeman H. The relation between inflammatory biomarkers and drug pharmacokinetics in the critically ill patients: a scoping review. Crit Care. 2024;28(1):376. doi: 10.1186/s13054-024-05150-4
16. Zhang B, Lin L, Yuan F, et al. Clinical application values of neutrophil-to-lymphocyte ratio in intracranial aneurysms. Aging (Albany NY). 2021 ;13(4):5250-5262. doi: 10.18632/aging.202445
17. Sproston NR, Ashworth JJ. Role of C-reactive protein at sites of inflammation and infection. Front İmmunol. 2018;9:754. doi: 10.3389/fimmu.2018.00754
18. He C, Wu D, Wei X, Li Y, Liao Y, Yang D. Association between Inflammatory Burden Index and all-cause mortality in the general population aged over 45 years: data from NHANES 2005-2017. Nutr Metab Cardiovasc Dis. 2024;34(1):64-74. doi: 10.1016/j.numecd.2023.10.006
19. Fleck A. Clinical and nutritional aspects of changes in acute-phase proteins during inflammation. Proc Nutr Soc. 1989;48(3):347-54. doi: 10.1079/pns19890050
20. Sun X, Lin J, Wang Z, et al. Association between C-reactive protein to lymphocyte ratio and gallstones: a cross-sectional study. BMC Gastroenterol. 2025;25(1):415. doi: 10.1186/s12876-025-04000-z
21. Dolan RD, McMillan DC. The prevalence of cancer associated systemic inflammation: implications of prognostic studies using the Glasgow Prognostic Score. Crit Rev Oncol Hematol. 2020;150:102962. doi: 10.1016/j.critrevonc.2020.102962
22. Cong M, Song C, Xu H, et al; Investigation on Nutrition Status and Clinical Outcome of Common Cancers (INSCOC) Group. The patient-generated subjective global assessment is a promising screening tool for cancer cachexia. BMJ Support Palliat Care. 2022;12(e1):e39-e46. doi: 10.1136/bmjspcare-2020-002296
23. Frenkel A, Novack V, Bichovsky Y, Klein M, Dreiher J. Serum albumin levels as a predictor of mortality in patients with sepsis: a multicenter study. Isr Med Assoc J. 2022;24(7):454-459.
24. Wu D, Wang X, Shi G, Sun H, Ge G. Prognostic and clinical significance of modified Glasgow Prognostic Score in pancreatic cancer: a meta-analysis of 4,629 patients. Aging (Albany NY). 2021;13(1):1410-1421. doi: 10.18632/aging.202357
25. Saal J, Bald T, Eckstein M, et al. Integrating on-treatment modified Glasgow Prognostic Score and imaging to predict response and outcomes in metastatic renal cell carcinoma. JAMA Oncol. 2023;9(8):1048-1055. doi: 10.1001/jamaoncol.2023.1822
26. Son HJ, Park JW, Chang HJ, et al. Preoperative plasma hyperfibrinogenemia is predictive of poor prognosis in patients with nonmetastatic colon cancer. Ann Surg Oncol. 2013;20(9):2908-13. doi: 10.1245/s10434-013-2968-8
27. Chan JC, Chan DL, Diakos CI, et al. The lymphocyte-to-monocyte ratio is a superior predictor of overall survival in comparison to established biomarkers of resectable colorectal cancer. Ann Surg. 2017;265(3):539-546. doi: 10.1097/SLA.0000000000001743
Article available in :
Volume 3, Issue 3, 2026
Page : 56-62
https://doi.org/10.51271/EAJAIC-0055
Article Information
Received : 19 Nis 2026
Accepted : 12 Haz 2026
Published : 29 Ağu 2026
Corresponding Author :

Veysel Garani Soylu: Department of Intensive Care, Faculty of Medicine, Kastamonu University, Kastamonu, Turkiye

[email protected]
Citation : Soylu VG, Yılmaz A, Taşkın Ö, et al. Association of inflammatory markers (Inflammatory Burden Index, Systemic Inflammation Response Index, Systemic Immune-Inflammation Index) and modified Glasgow Prognostic Score with 30- and 90-day mortality in a level 3 surgical intensive care unit. Eur J Anesthesiol Intens Care. 2026;3(3):56-62. doi:10.51271/EAJAIC-0055

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